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A National Institute on Aging (NIH) ginkgo trial of more than 200 healthy adults older than 60 showed no improvement in memory or concentration. It is possible that doses higher than the 120 milligrams used daily in this six-week trial could be effective. Look for results of current large, long-term trials, such as the National Center for Complementary and Alternative Medicine’s study with 3,000 volunteers. These will help to confirm whether or not ginkgo biloba can help prevent dementia or enhance memory in healthy people.

2.07am Awake! Random memories keep popping up, things I’ve not thought of in years. A delicious milkshake at Disneyland in 1994, a random 3am beach trip at uni with a girl I’d just met plays out in my mind, frame by frame. My head is uncomfortable. Not painful, just uncomfortable. Must sleep.

Among the most prestigious fatty acids known to support cognitive health are Omega-3 fish oil (EPA and DHA), Phosphatidylserine (PS), and Coconut Oil (MCT Oil). These are extensively studied natural smart drugs that support many cognitive abilities. Fatty acids play an essential role in providing structural support to cell membranes. They also contribute to the growth and repair of neurons. Both functions are crucial for maintaining peak mental acuity as you age.

Piracetam is a cognitive enhancer and memory enhancing supplement. Many people across the world use the nootropic, piracetam, to effectively retain knowledge and improve memory. Piracetam is utilized by both younger and older healthy individuals. From recent and past clinical studies and research, Piracetam has been determined to support memory and aid individuals experiencing memory loss and difficulties in the ability to retain knowledge. Piracetam may enhance, elevate, and improve cognitive functions and abilities linked and associated to the central nervous system, memory development and memory processes. Piracetam may benefit with senile dementia, dyslexia, alcoholism & withdrawal syndrome, acute ischemic stroke, circulatory disorders, heart disease, Raynaud’s, alzheimer’s disease, cortical myoclonus, obsessive-compulsive disorders (OCD), and traumatic brain injury (TBI). Piracetam is a nootropic nutraceutical that may improve and enhance memory and other intellectual functions. Piracetam is commonly prescribed for cognitive impairment and dementia in several countries of continental Europe. In a thorough clinical study and examination done by N. N. Zavadenko and L. S. Guzilova, piracetam was found to have positive therapeutic effects on impairments to the higher mental (memory, attention, executive) and motor (coordination) functions and on measures of the speeds of cognitive and motor operations. The nootropic substance, piracetam, has been studied in countless widespread clinical experiments. Piracetam has demonstrated inarguable results in the treatment of post-stroke aphasia, epilepsy, cognitive decline following heart and brain surgery, dementia, and myoclonus. Piracetam’s vascular effect has designated its use for patients suffering from vertigo, dyslexia, and sickle-cell anemia.

Adderall, nicknamed “Addy” by students, is the most popular study drug on college campuses around the country, according to scientists. Students say the drug boosts cognitive function and enables them to study for hours with full concentration without getting fatigued.

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Some data suggest that cognitive enhancers do improve some types of learning and memory, but many other data say these substances have no effect. The strongest evidence for these substances is for the improvement of cognitive function in people with brain injury or disease (for example, Alzheimer’s disease and traumatic brain injury). Although “popular” books and companies that sell smart drugs will try to convince you that these drugs work, the evidence for any significant effects of these substances in normal people is weak. There are also important side-effects that must be considered. Many of these substances affect neurotransmitter systems in the central nervous system. The effects of these chemicals on neurological function and behavior is unknown. Moreover, the long-term safety of these substances has not been adequately tested. Also, some substances will interact with other substances. A substance such as the herb ma-huang may be dangerous if a person stops taking it suddenly; it can also cause heart attacks, stroke, and sudden death. Finally, it is important to remember that products labeled as “natural” do not make them “safe.”

Panax ginseng: Most people are aware of the herb “ginseng.” It is found in North America and throughout Asia and has been used throughout history as a form of alternative medicine. Traditionally it was used as an aphrodisiac or to help with sexual dysfunction, and others have suggested that it can help control Type 2 diabetes. In any regard, ginseng is commonly found in products like energy drinks, teas, and certain types of coffee. The specific “Panax” species of ginseng has been found to: improve accuracy of memorization, increase quickness in attentional-task performance, and enhancing performance of complex arithmetic tasks.

As I put the tablets aside, I look out over my flat. My desk is piled high with the vast quantities of work I have pumped out. My cupboards are full of uneaten food. The whole place is freakishly clean, something I did in my spare time, without even thinking about it. Ah, Provigil, you are a gorgeous temptress. With a sad sigh, I close the bathroom cabinet on her sweet temptation, and stumble back to my slow, patchy life, with my slow, patchy brain.

It’s not an amphetamine or stimulant, the article explained: it doesn’t make you high, or wired. It seems to work by restricting the parts of your brain that make you sluggish or sleepy. No significant negative effects have been discovered. Now students are using it in the run-up to exams as a “smart drug” – a steroid for the mind.

He finds it suppresses divergent thinking, which is one part of intelligence, “but I think I’m too divergent. I never finish stuff. This helps me focus.” Mostly, though, he compares it to a “really good cup of coffee that lasts all day”.

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Some compounds which fall into this category are Sunifiram, Aniracetam, and Oxiracetam. Of these, Aniracetam is considered extremely potent, and also carries excellent anti-anxiety and anti-depressant benefits.

Jump up ^ Geng J, Dong J, Ni H, Lee MS, Wu T, Jiang K, Wang G, Zhou AL, Malouf R (2010). “Ginseng for cognition”. Cochrane Database Syst Rev (12): CD007769. doi:10.1002/14651858.CD007769.pub2. PMID 21154383.

Instead of risking your health with these prescription drugs, there are a number of over-the-counter nootropic supplements that perform equally well and are legal to purchase online. There is no need for an internet grey market, and no need to shop on international pharmacies.

When it comes to long term effectiveness and safety, its effects haven’t been determined. It is thought that Modafinil may have adverse interactions on hormonal contraception which can last for more than a month after the last Modafinil dose. But all medications can be un-safe make sure you consult a doctor before taking any medication.

While it is illegal to sell modafinil in the UK without a prescription, it is not illegal to buy. There are many websites, often based in India, which make it available to purchase – though the UK’s Medicines and Healthcare Products Regulatory Agency warn this can be unsafe.

Jump up ^ “Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy. US Modafinil in Narcolepsy Multicenter Study Group”. Annals of Neurology. 43 (1): 88–97. January 1998. doi:10.1002/ana.410430115. PMID 9450772.

When you are determining whether nootropic drugs are right for you, it is a good idea to see where your goals are in life. If you are trying to be healthy and don’t need to be at a higher level of performance, it may not be in your best interest to get these. If you want to be more alert, remember things better, and generally function in a more efficient way, then the smart drugs are probably a good idea. These tasks are all possible with the right dosage and type. Just make sure you buy nootropics that are good quality with independent third-party testing.

4. Qualia – at Nootropedia we are generally skeptical of combined nootropic blends and stacks, but Qualia does seem to be relatively ground-breaking within the space. It seems that no expense is too great for their formulation, which means 42 ingredients, 2 parts, and a guidebook on how to use the stack best.

Hordenine: This is a substance that falls under the phenethylamine classification and is a derivative of barley. It is an herb that is sold in many supplements and touted as improving metabolic functions and stimulating the central nervous system. It is thought to increase arousal, and when taken in significant dosages, it may increase blood pressure. There is a lack of research involving hordenine supplementation among humans, so any nootropic claims of increased concentration should be taken with skepticism.

I had considered smart drugs to be
 on a par with a strong cup of coffee; something to help when deadlines loom. But higher intelligence? Enhanced powers of creativity? This is what I want. I decide to proceed and drop my dexy, pledging to take notes as I go in the spirit of analysis. Come at me, brain smarts.